Cellular adaptations
- Atrophy
- Senile atrophy
- Physiological aging of cells that affects all organs
- Includes the formation of lipofuscin deposits
- Lipofuscin is composed of lysosomal breakdown products including lipid polymers and protein-complex phospholipids that result from free radical injury and lipid peroxidation.
- Yellow-brown, granular pigments found in organs such as the heart, lung, colon, kidney, liver, and eye
- Caused by normal wear-and-tear
- Formed by the peroxidation of polyunsaturated lipids of subcellular membranes
- Senile atrophy